Thrombocytopenia (TBS)

Generally in humans, a normal platelet count ranges from 150,000 and 450,000 per l. Thrombocytopenia is the presence of relatively few platelets in blood. Decreased platelet counts can be due to a number of disease processes, the quantification of platelet associated immunoglobulin allow to the cause of thrombocytopenia is decreased ratio in pla...

Generally in humans, a normal platelet count ranges from 150,000 and 450,000 per l. Thrombocytopenia is the presence of relatively few platelets in blood. Decreased platelet counts can be due to a number of disease processes, the quantification of platelet associated immunoglobulin allow to the cause of thrombocytopenia is decreased ratio in platelet production or an increase in the ratio of destruction. Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by a low platelet count and mucocutaneuos bleeding. The autoantibodies are directed primarily to the platelet-specific receptors CD41a (GPIIb/IIIa) and CD42b (GPIb). As a result, the sensitized platelets are rapidly cleared by the monocyte-macrophage cell systems. The determination of autoantibodies against thrombocytes allows differentiate immune from nonimmune thrombocytopenia.

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