Basophil activation by allergens (BASOSTEP)

Determination of basophil activation upon allergen estimulation by Flow Cytometry. Using defined allergens, this test provides information concerning the releasability of IgE-bearing basophils. When IgE-receptors on basophils are cross-linked by an allergen the cells undergo degranulation throught cytoplasmatic granules containing the CD63 trans...

Determination of basophil activation upon allergen estimulation by Flow Cytometry. Using defined allergens, this test provides information concerning the releasability of IgE-bearing basophils. When IgE-receptors on basophils are cross-linked by an allergen the cells undergo degranulation throught cytoplasmatic granules containing the CD63 transmembrane protein fuse with the plasma membrane and release inflammatory mediators. Therefore the CD63 antigen is exposed as a marker of basophil activation.

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