DY634 Annexin V Apoptosis Detection Kit with PI

Reference Size Price Quantity Add to cart
ANXVKDY-100T 100 test
261,00 €

Product Description

  • Flow Cytometry
  • DY634 (APC Alternative)
  • All mammalian
  • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
  • RUO
  • Store in the dark at 2-8 ºC
  • Link

Apoptosis is characterized by a variety of morphological features. One of the earliest indications of apoptosis is the translocation of the membrane phospholipid phosphatidylserine (PS) from the inner to the outer leaflet of the plasma membrane. Once exposed to the extracellular environment, binding sites on PS become available for Annexin V, a 35-36 kDa, Ca 2+-dependent, phospholipid binding protein with a high affinity for PS. The translocation of PS precedes other apoptotic processes such as loss of plasma membrane integrity, DNA fragmentation, and chromatin condensation. As such, Annexin V can be conjugated to biotin or to a fluorochrome, and used for the easy, flow cytometric identification of cells in the early stages of apoptosis.

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Moran J et al. Effects of Estrogen and Phytoestrogen Treatment on an In Vitro Model of Recurrent Stroke on HT22 Neuronal Cell Line. 2016 Cell Mol Neurobiol.

Chamorro-Garcia, R. et al. AF10 Plays a Key Role in the Survival of Uncommitted Hematopoietic Cells. PLoS One. 2012; 7(12): e51626.

Menacho-Márquez M. et al. The Rho Exchange Factors Vav2 and Vav3 Favor Skin Tumor Initiation and Promotion by Engaging Extracellular Signaling Loops. PLoS Biol. 2013 Jul; 11(7): e1001615

  • Annexin A5 
  • 308
  • 35,9 kDa

Tech Data Sheet

TDS_ANXK.pdf

Technical Data Sheet

Material safety Data Sheet

MSDS_ANXVK-PI_EN_RUO.pdf

Technical Data Sheet