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Tissue / cell preparation (Human). Fresh human lymph node lymphocytes depleted of surface immunoglobulin positive cells were used as the immunogen. This antigen is a single chain glycoprotein which is expressed on B cells, monocytes, and T cell subsets.
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
CD45RA, clone GRT22 is a mAb intended for the identification/enumeration of helper/inducer T-cell subset and CD45RA+ cells using FCM. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
This antibody reacts with the CD45RA-antigen. GRT22 recognizes all CD45 molecules containing the A region exon. Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes. CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes