The minimum purchase order quantity for the product is 1
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Human neuroblastoma cells
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
CD57, clone HI57a, is a mAb valid for the for identification of antigen CD57 expressed on a subset of NK cells and NK T cells. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
This antibody reacts with the CD57-antigen, a carbohydrate antigen present on a subset of peripheral blood mononuclear cells involved in the Natural Killer activity, which is not MHC restricted. The antigen is not present on B cells, monocytes, red blood cells or platelets but is expressed on cells in neuroectodermal tissue. It reacts with 20% of normal human peripheral blood mononuclear cells. Reacts with a 110 kDa carbohydrate antigen associated with myelin-associated glycoprotein expressed on 7-35% of normal peripheral blood lymphocytes including a subset of natural killer cells, a subset of CD8+ peripheral blood suppressor/cytotoxic T cells, and on some neural tissues.
CD57 is not expressed on granulocytes, platelets, red blood cells or thymocytes. The function of CD57 is still unclear, however, its expression on T-cell subets occurs in late immune responses.