PURE - anti Human CCND - 02im02107

Reference Size Price Quantity Add to cart
CCND2ACMO 0,1 mg
253,00 €

Product Description

  • 02im02107
  • IgG
  • WB
  • PURE
  • CCND2 sequence length recombinant protein (289 a.a.) with GST
  • Human
  • PBS, 0,09% sodium Azide, may contain carrier protein-stabilizer
  • RUO

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors.