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Human Antibodies
FITC - anti Human anti-MNDA - 3C1
| Reference | Size | Price | Quantity | Add to cart |
|---|---|---|---|---|
| MNDAF-100T | 100 test |
260,00 €
|
Product Description
- 3C1
- IgG1
- FCM
- FITC
- Please refer to the Certificate of Analysis for the lot-specific concentration.
- concentrated nuclear protein extract prepared from late stage human myeloid leukemia HL-60 cells
- Human
- The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
- RUO
- MNDA antibody, clone 3C1, is intended for identification of Myeloid nuclear differentiation antigen. This reagent is effective for direct IF staining of human tissue for FCM analysis using ≤1 μg/106 cells.
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This antobody is a 407 amino acid nuclear hematopoietic protein of the interferon inducible p200-familiy proteins, and its encoding gene is located at chromosomal band 1q21-22 (23, 24). It is capable of DNA binding and mediating protein–protein interaction, thereby slowing down proliferation, modulating cell survival and promoting differentiation (25). MNDA is expressed in maturating normal and neoplastic myelomonocytic cells, a subset of lymphocytes and some lymphomas but not in other human cells or tissues. Its expression mounts with differentiation, the highest expression shown in mature granulocytes and monocytes (23, 26). MNDA expression has been proven to be diminished on mRNA and protein levels in patients with familial and sporadic MDS (25, 27, 28)
- myeloid cell nuclear differentiation antigen
- 4332
