FITC - anti Mouse CD152 - UC10-4F10-11

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331,00 €

110,00 €

69,00 €

Product Description

  • UC10-4F10-11
  • Armenian Hamster IgG
  • Flow Cytometry
  • FITC
  • 0.5 mg/ml
  • Mouse CTLA-4 IgG2a Fusion
  • Mouse
  • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
  • RUO
  • CD152, clone UC10-AF10-11, is a mAb intended for RUO in the identification/enumeration of lymph that express CD152. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 µg/106 cells.
  • Store in the dark at 2-8 ºC
Mouse FITC Vial View larger
CD152 also known as, Cytotoxic T-lymph ocyte-associated antigen 4 (CTLA-4). CD152 is expressed on activated T lymph ocytes 2-3 days after stimulation through T cell receptor. CTLA-4 has significant similarity to CD28 in amino acid sequence, structure, and genomic organization. Furthermore, CD152 and CD28 share common B7 family counter-receptors. Unlike CD28, CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T (Treg) cells. Whereas CD28 delivers a costimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses. CD152 may play roles in induction and/or maintenance of immunological tolerance, regulation of protective immunity, and autoimmune responses, and regulation of some aspects of thymocyte maturation. This hamster mAb to a mouse leukocyte antigen does not cross-react with rat leucocytes.
  • Ctla4; CTLA-4; Cytotoxic T-lymph ocyte-associated protein 4; Ly-56
  • 12477
  • 33 kD

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Technical Data Sheet