PE - anti Mouse CD314 - C7

Reference Size Price Quantity Add to cart
MO314PE(V50) 50 µg
192,00 €

Product Description

  • C7
  • Armenian Hamster IgG
  • Flow Cytometry
  • PE
  • 0.2 mg/ml
  • Soluble mouse NKG2D
  • Mouse
  • The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium azide (NaN3)
  • RUO
  • CD314, clone C7, is a mAb intended for RUO in the identification/enumeration of lymph that express CD314. This reagent is effective for direct IF staining of mouse sample for FCM analysis using ≤1 µg/106 cells.
  • Store in the dark at 2-8 ºC
CD314 View larger
CD314is a lectin-like type II transmembrane protein also known as CD314. It is expressed on NK cells, a subset of CD8+ T cells, ?/? T cells and NK1.1+ T cells, as well as in vitro induced LAK cells. NKG2D serves as a stimulatory immunoreceptor to activate NK cells via the non-covalently associated DAP10 or DAP12 adaptor. Several molecules have been identified as the ligands for NKG2D, including minor histocompatibility molecule, H60, UL16-binding protein-like transcript 1 (Mult1, and a family of retinoic acid early transcript 1 (Rae1) in mice, MHC class-I chain-related protein A (MICA), MICB, and UL16-binding proteins (ULBPs) in humans. present in both mice and humans. NKG2D ligands trigger cytokine (IFN-?, GM-CSF, TNF-?, MIP1? and others) and granzyme release from NK cells. The C7 antibody has been reported to block NK cell killing of targets expressing NKG2D ligands and induce redirected lysis.
  • CD314
  • 27007
  • 27 kD

Tech Data Sheet


Technical Data Sheet

Material safety Data Sheet


Technical Data Sheet